According to Technical Note TN2459 from Apple, "macOS High Sierra 10.13 introduces a new feature that requires user approval before loading newly-installed third-party kernel extensions (KEXTs)." Additionally, Technical Note TN2459 from Apple indicates, "[t]his feature enforces that only kernel extensions approved by the user will be loaded on a system."
When a request is made to load a KEXT that the user has not yet approved, the load request is denied and macOS presents the alert with a System Extension Blocked message.
Resolution
Enable Palo Alto Networks as a trusted developer.
For users who have installed global protect, but are unable to connect the following steps have resolved the issues for most users.
Users may see a more detailed screen, as in the example below. If you see this screen, verify that you have “App Store and identified developers” selected.
Verify that the software you are allowing is named where it says “System software from developer…” Here you should see “Global Protect”. Click Allow.
RELATED KNOWLEDGE BASE ARTICLES: Not registered for Duo? Do you need to install Global Protect? Please refer to the following KB Articles for assistance or call the IT Service Desk at 334-844-4944